What are the clinical applications of vagus nerve stimulation?

Treatment-resistant epilepsy: This is the primary clinical application area for vagus nerve stimulation. For patients whose seizures remain uncontrolled despite adequate dosage and treatment with multiple antiepileptic drugs, vagus nerve stimulation can reduce the frequency, duration, and severity of seizures by regulating abnormal brain discharges. It is particularly suitable for patients who cannot undergo surgical resection of the epileptic foci.

 

Treatment-resistant depression: This is suitable for patients with treatment-resistant depression whose symptoms recur or show no significant relief after repeated treatment with antidepressants and psychotherapy. By stimulating the vagus nerve to regulate the balance of neurotransmitters in the brain, it can alleviate core symptoms such as low mood and loss of interest, helping patients improve their mental state and quality of life, serving as an important supplement to drug therapy.